Bioregeneration with RETIX.C RESTEEME

Next-generation bioregeneration with RETIX.C RESTEEME respects the skin’s natural physiology.

Improving skin quality without drastic interference with its natural physiology was the goal of the RETIX.C brand, part of the pharmaceutical company URGO Aesthetics, when developing the next-generation bioregenerative preparations RESTEEME. They quickly became a sensation among aesthetic medicine professionals, as they allow for rejuvenating results due to advanced formulas with carefully selected molecular weight hyaluronic acid. Therefore, RESTEEME preparations are considered optimally compatible with the skin’s natural physiology and have the potential to naturally stimulate skin regeneration processes.
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Why choose bioregeneration with RETIX.C RESTEEME?

1 – Formulas respecting skin physiology
RESTEEME preparations consist of non-crosslinked hyaluronic acid with varying molecular chain lengths, which are highly biocompatible. This allows for a natural targeted effect without drastic impact on the skin’s natural physiology: low molecular weight hyaluronic acid activates regeneration, medium weight hydrates, and high weight provides a subtle lifting effect.

2 – Trehalose for prolonged hyaluronic effect
One of the RESTEEME line products contains an innovative, patented* combination of hyaluronic acid and trehalose. Trehalose is a natural sugar that protects hyaluronic acid from enzymatic degradation, extending its action in tissues by up to 54%**. This helps maintain long-term hydration and enhances bioregeneration results.
*Patent No. US 2021/0315804 A1
Complife laboratory study “Evaluation of the susceptibility of a hyaluronate-based product to the activity of hyaluronidase” (E.IT.076_2018/2116 B)

3 – Antioxidation and impact on glycation
Trehalose is known for its antioxidant effects—it helps reduce oxidative stress, suppress inflammatory processes, and slow down glycation. Managing these processes is crucial for maintaining healthy, smooth, and youthful-looking skin, as oxidative stress and glycation are among the main internal factors of skin aging.
During glycation, sugars bind to collagen and elastin proteins, causing them to lose their structure, become brittle, and less functional—manifesting as reduced skin firmness, wrinkle formation, and a dull complexion. Trehalose, acting together with hyaluronic acid, helps protect these vital proteins and maintain skin elasticity, radiance, and resilience against harmful environmental factors.

4 – Changes after the first procedure
Due to the innovative RESTEEME formula with patented hyaluronic acid and trehalose combination, clinical and instrumental studies have shown that changes in skin quality are noticeable after the first procedure. Increased skin moisture levels, improved elasticity and firmness, and reduced redness are observed.

5 – Cumulative effect
The long-term effect of active ingredients in tissues ensures that results not only persist but also strengthen with each subsequent procedure. This cumulative effect ensures comprehensive skin regeneration and allows for visible yet natural changes without excessive invasiveness.

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How many procedures will I need?

Three procedures performed weekly (every 7 days) constitute an intensive initial course aimed at activating bioregeneration. After the initial course, maintenance procedures can be performed once a month, depending on skin condition and individual needs. This frequency allows active ingredients to accumulate effectively in tissues and maximize bioregeneration processes. A personalized therapy schedule is created by the doctor individually, considering the patient’s skin condition, age, goals, and selected preparations.

What results can be expected?

RESTEEME line products have multifunctional effects on the skin—they not only improve its aesthetic appearance but also activate natural regeneration processes. Instrumental studies have confirmed improved skin moisture levels and elasticity, reduced redness, increased skin thickness and density. Patients often notice smoother skin texture, reduced fine lines, improved firmness, brighter tone, and overall rejuvenated skin appearance. With each procedure, results become more noticeable.

RESTEEME X helps restore skin structure, promotes intensive bioregeneration, and reduces glycation effects—skin becomes smoother, firmer, and visually younger.

RESTEEME L improves skin firmness, increases its density and elasticity—skin becomes more resilient to gravity, and facial contours become more defined.

RESTEEME H restores deep hydration and gives the skin radiance—skin becomes plumper, glowing, soft, and comfortable.

During a single procedure, one selected preparation can be used, or, depending on individual skin needs in different areas, several products can be combined to create personalized therapy at different skin depths.

Is bioregeneration with RESTEEME suitable for me?

The procedure is recommended from the age of 30—for both women and men—who notice the first signs of skin aging or seek preventive effects. For skin that has lost elasticity, appears tired, dehydrated, has superficial scars or uneven texture. Bioregeneration with RESTEEME is also suitable after significant body weight changes (“Ozempic face”), after hyaluronidase procedures, and for those who avoid contouring hyaluronic preparations. RESTEEME X is considered an excellent solution for active individuals—their skin breaks down hyaluronic acid faster, so the formula supplemented with trehalose helps maintain hydration longer.

It should not be performed on pregnant and breastfeeding women, individuals with increased sensitivity to hyaluronic acid or other product components, those with autoimmune diseases or undergoing immunotherapy, and those prone to hypertrophic scar formation. For those taking anticoagulants or antiplatelet agents, consultation with the prescribing doctor is necessary. Not applicable to skin areas with active inflammation or infection (e.g., acne, herpes).

What will I look like after RESTEEME injections?

After the procedure, temporary redness, swelling, or sensitivity may occur, usually subsiding within 1–2 days. If the procedure is performed using microinjection technique, papules may form on the skin, typically disappearing within 2–3 days, but in some cases may persist for up to a week. This is a normal reaction indicating product activity; however, if you are preparing for important events or celebrations, discuss the recovery period after the procedure with a specialist.

When will the procedure’s effect be visible?

The first results—improved skin moisture, radiance, and softness—can be felt after the first procedure. The regenerative effect strengthens with each subsequent procedure, and noticeable results usually become apparent within 2–4 weeks, during which the product’s effect unfolds and skin renewal processes are activated.

What should the patient know about RESTEEME?

These are professional aesthetic medicine preparations for injection procedures, which can be performed on patients from 18 years of age. For optimal results, it is important to rely on a doctor who will create an individual plan. Significant and long-lasting skin quality changes can be expected only after completing a course of procedures and following skin care recommendations.

Can RESTEEME be combined with other procedures?

It is recommended to combine with microneedling mesotherapy procedures (e.g., R-Pen), retinol therapy (e.g., Retibooster®), mild superficial peels, LED phototherapy, as well as cosmetic care procedures between injections. Such combinations help enhance skin renewal, improve moisture balance, stimulate collagen synthesis, and prolong the achieved effect. Procedures should be scheduled separately to avoid skin irritation.

RESTEEME is not recommended to be combined with procedures that severely damage the skin in the same area, especially on the same day. This includes aggressive chemical peels, fractional lasers, dermabrasion, and volume-enhancing hyaluronic fillers.